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Since the brain atrophy progressed as mice aged (Fig

VLDL can then transport fats in the bloodstream to various target organs, such as the skeletal muscles (where fats are used for energy) or adipose tissue (where they built into fat stores)

2014

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Its clinical program in the late 2000s was built around large, rigorously controlled trials with a hard imaging endpoint (visceral adipose tissue measured by CT), and it culminated in FDA approval in 2010