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Additionally, among SASP factors, there are growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and insulin-like growth factor 1 (IGF-1), which, when secreted into the environment by senescence cells, stimulate the repair and regeneration of surrounding tissues [13]

The complexes cause an influx of neutrophils, macrophages, and other B cells and T cells into the tissue Proinflammatory cells secrete damaging reactive oxygen species and more proteins that cause tissue damage

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10.1177/44.10.8813074 J

doi: 10.1038/s41467-022-29440-z 179 SadasivanS.ZaninM.O'BrienK.Schultz-CherryS.SmeyneR

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