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Cell 77 IshigakiA.AokiM.NagaiM.WaritaH.KatoS.KatoM.et al (2007)

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Together, these findings highlight that while ACE-inhibitory peptides remain the most extensively studied, peptide-based strategies in cardiovascular diseases potentially extend beyond blood pressure regulation to include vascular repair, plaque stabilization, and endothelial modulation

Minimal changes in heart rate indicate cardiovascular safety