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Finally, the molecular signatures identified here provide a mechanistic framework that is consistent with previously reported clinical observations at comparable dosing in a prior study 22

Missing data was replaced by the mean when possible (see supplemental Table S11) eGFR was calculated using MDRD formula without race consideration: GFR, in mL/min per 1.73 m 2 = 175 SCr (exp[1.154]) Age (exp[0.203]) (0.742 if female)

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