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This triple receptor activity is the defining mechanistic feature that distinguishes Retatrutide from related compounds: Semaglutide acts on GLP-1R alone, while Tirzepatide targets GLP-1R and GIPR without glucagon receptor involvement
Ethical Approval This article does not contain any studies with any animals or human participants performed by any of the authors
The SURPASS-CVOT trial, evaluating cardiovascular outcomes with tirzepatide, is ongoing
Otani, K
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