As the most abundant intracellular antioxidant, reduced glutathione (GSH) functions not merely as a scavenger of reactive oxygen species (ROS), but as a pivotal modulator of redox-sensitive enzymatic activity, mitochondrial integrity, inflammatory signaling, and metabolic resilience and flexibility
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February 8, 1968
In addition, 5-demethylnobiletin can stimulate dendritic structure formation, melanin synthesis, and melanosome transport in B16F10 melanoma cells by activating the cAMP/CREB pathway [233]