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The following side effects have been reported in subjects taking 3mg liraglutide for weight loss [24]: Nausea (39.3%) Diarrhea (20.9%) Constipation (19.4%) Vomiting (15.7%) Headache (up to 13.6%) Increases in mean resting heart rate (over 10% ) Less common side effects that occur in less than 10% of patients are: Dyspepsia Abdominal pain Gastroesophageal reflux disease Eructation Flatulence Dry mouth Elevated pancreatic enzymes Constipation Gastritis Abdominal discomfort Hypoglycemia Dizziness Hypotension Injection site reactions (pain, bleeding, redness, swelling, or itching) Rare but serious side effects include pancreatitis, gallbladder disease, cholestasis, and allergic reactions
The biological effects of GH on cells, tissues, muscles, and organs are principally mediated by IGF -1 and we measure IGF-1 in the body to determine GH levels and pulsatility
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Systematic errors in measurement often explain apparent weight loss resistance
Mucosal Immunol 14(2):296304
In its Phase 2 obesity trial it produced the largest average body-weight reductions yet reported for a once-weekly agent but every gram of that effect was built on a slow, deliberate dose-escalation schedule
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