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The drug was administered to rats by dissolving metformin (Aladdin Inc., Shanghai, China) in water, and the drug concentration was adjusted according to changes in the amount of water consumed by the rats to ensure that the daily dose of the drug ingested was approximately 200 mg/kg/d

4.1.2 SNAT1 and SNAT2 Targeting SNAT1 and SNAT2, encoded by SLC38A1 and SLC38A2 respectively, is the other intervention technique to reduce Gln uptake into nave CD4 + T cells because they are both capable of mediating Gln transport into cells (98)

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