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The international journal of biochemistry & cell biology , 37 (8), 17271737

101 (Pt A), 108175

A comprehensive review of the strategies to reduce retinoid-induced skin irritation in topical formulation

GSH conjugation differs from other conjugation reactions in that the process does not require initial activation of the coenzyme or the substrate since the GSH, which is a nucleophile itself, is highly reactive towards an electrophilic substrate

This reprograms SMA CAFs into collagen-III inflammatory CAFs (iCAFs), forming a fibrotic niche that supports CD44 CSCs, thereby fueling chemoresistance

10.1038/s41591-019-0423-5 299 WeiZ.SongJ.WangG.CuiX.ZhengJ.TangY.et al