Epidemiological data consistently shows lower skin cancer incidence in individuals with higher baseline melanin (Brenner & Hearing, 2008)
For instance, in B-cell lymphoma, inhibition of the pentose phosphate pathway (PPP) metabolically reprograms macrophages via the UDPG-Stat1-Irg1-itaconate axis, thereby enhancing phagocytic clearance of lymphoma cells (79)
Weight loss also leads to a decrease in GLP-1 and changes other appetite-related hormones, which can prompt you to eat to get back up to your baseline weight
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