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These changes cannot occur without reducing the central cobalt ion from the + 3 oxidation state to + 2 or + 1 because cobalamins with a Co + 3 central ion are stable six-coordinate systems

This structural plasticity translates to improved information processing and memory encoding capacity in treated animals

The increase in glutathione abundance was due to a proportional rise in both the reduced (GSH) and oxidized (GSSG) forms of glutathione

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Most side effects are mild, like nausea or constipation, and usually decrease as treatment continues