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Investigation into the efficacy and safety profile of oral small-molecule GLP-1 receptor agonists in type 2 diabetes and obesity: a systematic review and meta-analysis

In topline results from the phase 3 SUMMIT study, Lillys dual GIP/GLP-1 receptor agonist tirzepatide cut the risk of heart failure outcomes by 38% compared to placebo in adults with heart failure with preserved ejection fraction (HFpEF) and obesity

In the UK, commonly prescribed GLP-1 medications include semaglutide (Ozempic for diabetes, Wegovy for weight management), liraglutide (Victoza for diabetes, Saxenda for weight management), dulaglutide (Trulicity for diabetes), and tirzepatide (Mounjaro for diabetes), which is a dual GLP-1 and GIP receptor agonist

Tell your provider you're starting tirzepatide so they can monitor your BP closely and reduce doses if needed

Dosage can have a major impact on how quickly you notice results

The side effects are similar to the injectible version, with nausea, diarrhoea, constipation and vomiting among the most commonly reported particularly when starting treatment, pharmacist Thorrun Govind explains