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Biol Chem 398(10):10951108

Data are mean SEM, n = 8/group

The combination therapy of metformin and CDDP weakens ERK-mediated phosphorylation of NRF2, enhances its polyubiquitination, and promotes its proteasomal degradation, thereby significantly reducing the levels of NRF2 in A549/DDP and H838 NSCLC cells, promoting ROS-mediated apoptosis

[3] : 313 The most common cause in developed countries is impaired absorption due to loss of gastric intrinsic factor (IF), required for absorption

Another study reported that levels of antioxidants in seminal plasma from infertile men were significantly lower than levels in fertile controls

The itching associated with hemorrhoids can be attributed to several factors, all of which can create discomfort and lead to a cycle of irritation