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It activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously

Beyond reduced heart disease risk that comes with weight loss, there's growing evidence that these drugs yield health benefits beyond diabetes and weight loss

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Together, these data make retatrutide relevant for research on hepatic substrate flux, adipose-liver crosstalk, and integrated lipid metabolism [5][7][8]

4 and 5, Extended Data Fig

GI side effects and dose relationship Gastrointestinal symptoms are the most common adverse events reported with retatrutide, and they follow a clear dose-dependent pattern