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The 2.5mg starting dose is not considered therapeutic for weight loss

Caremark PA for the CV indication generally requires: Documented atherosclerotic cardiovascular disease (prior MI, prior stroke, or angiographically confirmed CAD) BMI 27 or higher Cardiology consultation or co-signature on the prescription Sometimes, documented statin therapy and other cardiovascular medications How to identify your Caremark template Caremark operates multiple formulary templates with different GLP-1 positions

In vitro and in vivo experiments in OA, RA and psoriasis models have demonstrated weight-loss-independent anti-inflammatory and chondroprotective effects of GLP-1RAs, commonly through inhibition of the NF-B pathway

References 1 Schernthaner-ReiterMHWolfPVilaGLugerA

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