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Additionally, most supplement ingredients face bioavailability challenges

There is some intriguing evidence that GLP-1 may actually reduce bloating in the long run by improving gut transit regularity and reducing intestinal inflammation

If the drug has too strong an effect in the lower intestine, slow GI motility leads to constipation, he said

The result is a decrease in appetite and an increase in satiety, making it easier to reduce caloric intake and promote weight loss