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doi: 10.1093/jexbot/53.372.1283 52 NoctorG.MhamdiA.ChaouchS.HanY.NeukermansJ.Marquez-GarciaB.et al

Folate usually helped very nicely to resolve the anaemia, but it resulted in severe neuropathy symptoms in many people because of the ongoing B12 deficiency

7 Limitations Although increasing evidence indicate natural supplements as effective anticancer agents, several deficiencies impede their clinical translation and generalization

If you already have adequate B12, the effect may be subtler

In addition, B12 must be activated in your body (through a methylation process) in order to be used correctly