Glutathione is one of the most powerful antioxidants and useful by products present in the human body , with increasing significance in the world of cosmetics and skin health
However, it is still unclear how melanocyte apoptosis is involved in the aetiology of vitiligo [37]
Specifically, it participates in the conversion of branched-chain amino acids (BCAAs) valine, leucine, and isoleucine into their keto analogs, a crucial function during fasting and exercise
Studies show oxidative degradation and peptide aggregation increase beyond this window, reducing bioavailability by 1020% or more depending on storage conditions
Glutathione is an antioxidant naturally occurring in the body and protects cells from damage caused by free radicals and toxins
In vitro experiments have demonstrated that loganin and catalpol can inhibit the expression of Nrf2, LC3, PINK1, and Parkin proteins in AGE-induced glomerular mesangial cells, thereby inhibiting the nuclear translocation of Nrf2 protein and the phosphorylation of p62
