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Consistently, deletion of miR-148a or miR-152 binding regions in 3UTR of IRS-1 did not exert the effect of miR-148a or miR-152 overexpression on inhibition of cell proliferation, indicating that these miRNAs affect cancer cell proliferation via IRS-1 suppression

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doi: 10.3390/ph16071052

Although limited, the evidence suggests that combined therapy has an enhanced effect in reducing cardiovascular events in selected populations and positively impacting important surrogate kidney disease markers