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Endpoints for metformin were derived from concentrationtime curves from the last dosing until 30 h after the last of seven repeated doses of metformin alone, with SNAC or with oral semaglutide at steady state (days 4, 20, and 78, respectively)

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A body composition substudy of the Phase 2 diabetes trial, published in The Lancet Diabetes & Endocrinology in 2025, used DXA scans to measure changes in fat and lean mass in 189 participants

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That structure shapes GLP-1 coverage in a distinctive way