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Oligodendrocytes and microglia are selectively vulnerable to combined hypoxia and hypoglycemia injury in vitro
Cross-trial comparisons reveal broadly similar efficacy, with differences in weight reduction and glycemic regulation
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However, many patients achieve excellent weight loss results at 1.0 mg or 1.7 mg and do not require the highest dose
Most retatrutide side effects mirror those of the broader GLP-class primarily gastrointestinal symptoms such as nausea, decreased appetite, and gastrointestinal upset
2021;320:H1486-1497
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