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An influx in calcium is reported upon activation of GLP-1R, and in combination with the activation of PKA, this results in insulin secretion [46]

The decision came after decades of debate, regarding whether obesity was a proper disease, or merely a behavioral issue, or a lifestyle choice

It is not approved for children, and should not be taken alongside other GLP-1 receptor agonists

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(2025), and the European Journal of Pharmacology paper by Abdul-Rahman et al