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Additionally, O 2 can react with nitric oxide (NO) to generate excessive ONOO, activating caspases, causing lipid peroxidation, and leading to either apoptosis or necrosis [49]
Piaggi, S
These adverse events have contributed to the discontinuation of several PDE10A candidates in clinical development (Grauer et al., 2009
Consistent with the pharmacological results, the above results provide convincing evidence that the GPX4 overexpression protects TECs from ferroptosis and mitigates renal interstitial fibrosis
Mancuso P, Bouchard B
To examine the similarity of peptides predicted by different models within each potency profile, we used PCA, considering the 500 one-hot-encoded sequences generated across all five compared models, the wild-type peptideshGCG and hGLP-1and their single-step mutants (551 hGCG and 570 hGLP-1), such that the projection was computed for an array [1,621 21 L ]
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