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Barton (2014) Optimizing IGF-I for skeletal muscle therapeutics Growth Hormone & IGF Research, Volume 24, Issue 5, October 2014, Pages 157-163
Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
Patients who took GLP-1 agonists for diabetes and weight loss experienced improvements in depressive symptoms, although the patients in those trials did not have clinical depression
Recruitment for Phase III clinical trials to assess the efficacy and safety of bepirovirsen is also underway, with results expected in early 2026 (NCT05630807 and NCT05630820)
But how exactly do these drugs work
Angiopoietin-2 (Ang-2) expression is elevated in brain microvascular endothelial cells (BMECs) and secreted Ang-2 can increase BBB permeability by disrupting tight junction protein structures between ZO-1 and Claudin-5 in TNBC models of brain metastasis (111)
