The primary concern with early administration is that you may still have higher levels of the previous dose circulating in your system, which could theoretically increase your exposure to the medication and potentially heighten the risk of adverse effects
But most people who have heard the name have no idea what it actually is, how it differs from older oral options, or whether it's the right fit for their metabolic goals
This is what I know: Buprenorphine, the opiate ingredient in Suboxone, is a partial (opiate) mu-agonist, which is the most obvious explanation why it has any analgesic properties at all
Gaither says its important to determine whether the medication is actually causing those changes or if they have another cause
Reference: Association between GLP-1 receptor agonist use and worsening mental illness in people with depression and anxiety in Sweden: a national cohort study by Heidi Taipale, Mark Taylor, Markku Lhteenvuo, Ellenor Mittendorfer-Rutz, Antti Tanskanen and Jari Tiihonen, April 2026, The Lancet Psychiatry
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