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Patients who fail to obtained symptomatic relief with medical therapy or who developed long term complications from reflux should consider surgical intervention

Because these are separate receptor populations using different second messenger systems, simultaneous activation produces additive-to-synergistic GH pulse amplification without receptor competition or off-target hormone effects

Stanley Medical Research Institute (USA)

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The American journal of clinical nutrition , 101 (2), 287-293

Dutta A, Sen J, Deswal R (2007) Downregulation of terpenoid indole alkaloid biosynthetic pathway by low temperature and cloning of a AP2 type C-repeat binding factor (CBF) from Catharanthus roseus (L)