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The gap detection task measured the acoustic startle response to a brief white noise pulse, and how this response was attenuated when preceded by a silent gap in the continuous background sound
, : -157 (BPC-157)
However, based on preclinical data and early human trial findings, glucagon receptor co-activation in the context of concurrent GLP-1R and GIPR agonism is hypothesised to: Increase energy expenditure, potentially by promoting thermogenesis Enhance hepatic fat oxidation, which may reduce liver fat content Contribute to appetite suppression through central nervous system pathways These GCGR-mediated mechanisms are largely derived from preclinical and indirect human data and require confirmation in larger trials
Improved diagnostic tools are essential to accurately strategy patient subgroups and reduce the risk of misclassification, which can obscure the interpretation of study findings
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