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The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function

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The STEP trials represent some of the largest and most rigorous weight loss intervention trials ever conducted, with outcomes that exceed what bariatric surgery achieved in trials a decade ago

At 7.2 mg (triple the standard maximum), participants lost an average of 13.2% of body weight compared to 10.4% at the standard 2.4 mg dose

By upregulating genes related to lipid peroxidation and iron absorption, p53 can cause ferroptosis