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demonstrated that, relative to the ad libitum group, the CR group showed markedly higher levels of bone resorption markers (CTX and TRAP5b), accompanied by a notable decrease in the bone formation marker bone-specific alkaline phosphatase (BAP)

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doi:10.1056/NEJMoa2206038 Rosenstock J, Wysham C, Fras JP, et al

Activation of GIP and GLP-1 receptors can initiate intracellular cyclic AMP signaling cascades and downstream regulatory pathways involved in cellular metabolic activity

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