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Primary hippocampal neuron cultures are used to study Dihexa's proposed effects on dendritic spine density and synaptic protein expression, typically measuring morphological changes via fluorescence microscopy and quantifying synaptic marker expression (such as PSD-95 or synaptophysin) relative to untreated controls
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second, SCFAs enhance insulin signaling in adipose tissue and liver via FFAR2/FFAR3 (GPR43/GPR41) receptor activation, and their deficiency directly exacerbates insulin resistance
The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders
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