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Mild nausea, fatigue, and constipation are common in the first 72 hours and usually fade by day 10

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It is very essential for each one of us to take care of our skin equally like any other task in our life

Despite the theoretical potential for multiple endogenous DPP-4 substrates to be affected and for the DPP-4 protein to have diverse actions, as discussed in the sections above, pooled safety analyses (119123), and large cardiovascular (CV) safety outcome trials (124127) with the individual drugs, which between them have included many thousands of patients (Table 2), have uniformly shown that DPP-4 inhibitors are well-tolerated and not generally associated with adverse effects

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Moreover, access and supply issues for these therapies remain a challenge, especially among our high-risk underserved populations who may benefit most from them