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About 10.3% of patients on the 36 mg dose stopped the drug because of side effects, compared with 2.6% on placebo
Some centres perform point-of-care gastric ultrasound to assess gastric volume and guide anaesthetic technique, though availability and expertise vary
When cytoplasmic catecholamine concentrations rise to levels that threaten to saturate both VMAT2 sequestration and mitochondrial monoamine oxidase (MAO) degradation pathways, the reversal of plasma membrane transporters provides a vital escape route (Underhill et al., 2021)
Only the sponsor's validated data can confirm both microbiological and chemical in-use stability for a specific IMP formulation
DOI: 10.1016/j.autrev.2009.02.020
detected in up to 75% of women attending health screening
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