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9,10 The culmination of these signaling events is oncotic necrosis 11 rather than apoptosis, 12 despite some overlap in mechanisms, such as the translocation of Bax and Bid to the mitochondria, 1315 mitochondrial cytochrome c release, 13,14,16 and DNA fragmentation, as indicated by DNA ladder formation 17,18 and TUNEL staining

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Amongst the dysregulated mediators, toll-like receptor (TLR) (4), nuclear factor-B (NF-B), and Nod-like receptor pyrin domain-containing (NLRP) (5), as well as the associated TLR/NF-B/NLRP pathway, have been shown to contribute to cancer chemoresistance

Am J Respir Crit Care Med 171 : 431439 Fitzpatrick AM, Brown LA, Holguin F, Teague WG, National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program 2009 Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma