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Moreover, it stimulates triacylglycerol hydrolysis, enhances glucose uptake, and suppresses cortisol synthesis in adipose tissues
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[] Recent research has identified a distinct AgRP-negative/NPY-high neuronal subpopulation that exacerbates obesity by suppressing POMC neurons through NPY Y2 receptor (Y2R), creating a maladaptive positive feedback loop under high-fat diets
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Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo
Long-term: no reliable long-term outcome data exists
