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Pharmacol Ther 240(1):108219 Scripture CD, Sparreboom A, Figg WD (2005) Modulation of cytochrome P450 activity: implications for cancer therapy

Abstract Acute tubular necrosis mediates acute kidney injury (AKI) and nephron loss 1 , the hallmark of end-stage renal disease 2,3,4

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These effects are partially mediated through PCSK9 inhibition, since berberine reduces PCSK9 expression, which allows LDL receptors to be recycled more effectively rather than degraded

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