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[12] This mechanism slows gastric emptying (most notably early in therapy), prolongs feelings of fullness, and reduces hunger signals in the brain , leading to decreased food intake and subsequent weight loss

Tarnowska K, Gruczyska-Skowska E, Kowalska D, Majewska E, Kozowska M, Winkler R (2023) The opioid excess theory in autism spectrum disorders - is it worth investigating further

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You essentially run through your supply at a higher rate