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Recent incorporation of PARP inhibitors and radioligands such as Lutetium-177 has improved the outcomes of castration-resistant prostate cancer (CRPC)
Cassandra F
It is relatively benign from a metabolic standpoint, and the body releases it fairly easily during a calorie deficit
Dysregulation in the FXR and TGR5 signaling pathways leads to hepatocyte toxicity due to an increase in primary bile acids like cholic acid (CA) and chenodeoxycholic acid (CDCA), as well as a decrease in secondary bile acids such as deoxycholic acid (DCA) and lithocholic acid (LCA), which in turn triggers microbiota dysbiosis and MASLD pathogenesis [249]
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