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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility
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doi:10.3389/fspor.2023.1281397
With the advancement of multi-omics sequencing technologies, including proteomics, transcriptomics, and metabolomics, alongside genetic code extension and machine learning, the mapping of lactylation networks, including lactylated proteins, specific modification sites, and protein function in various physiologies and pathologies, is anticipated to be elucidated more comprehensively
Analyses were based on the in-trial period, which was the time from randomization to the end-of-trial visit, death, withdrawal of consent or last contact with a trial site, whichever occurred first
Effects of GLP-1 receptor agonists on biological behavior of colorectal cancer cells by regulating PI3K/AKT/MTOR signaling pathway
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