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45 The lung resistance protein (LRP), encoded by the major vault protein (MVP) gene, contributes to MDR by mediating intracellular vesicular sequestration of drugs

Age-related decline in sleep quality, reduced cellular resilience, shortened telomeres, disrupted circadian rhythm, oxidative stress, and the biological markers of aging that accelerate after 35

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Damaged mtDNA impairs OXPHOS, reducing ATP production and increasing ROS

The result: increased systemic oxidative stress that can amplify fatigue, brain fog, and metabolic inflammation even as weight drops

Effects of N-Acetyl-cysteine on endothelial function and inflammation in patients with type 2 diabetes mellitus