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Additionally, GGCT knockdown concomitantly reduced 5- oxoproline (5-OP) levels in MHCC97H cells, consistent with 5-OP being the direct enzymatic product of GGCT activity, and exogenous 5-OP rescued proliferation under Gln-deprived conditions (Fig

By reducing melanin, glutathione can help lighten the skin and create a more even complexion

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Regulation of apoptosis by the redox state of cytochrome c

We further found that knockdown of GGCT significantly reduced the GSH concentration in HCC and PCa cells and increased ROS production using DCFH-DA fluorescence detection (Fig

doi:10.1016/j.reprotox.2004.02.012