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In the Phase 3 REDEFINE 1 trial, the most commonly reported adverse events included nausea, vomiting, diarrhoea, and constipation

Recent genomic and transcriptomic profiling of tumors of patients with GBM following treatment with PD-1 inhibitors nivolumab or pembrolizumab revealed a significant enrichment of PTEN mutations associated with immunosuppressive expression signatures in non-responders [107]

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