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The future oral GLP-1 receptor agonists, incretin dual agonists, triple agonists, and other new oral metabolic products will become popular only if they prove themselves capable of producing sustained results in obesity disease, type 2 diabetes, hypertension, dyslipidemia, cardiovascular risks, and metabolic syndromes through their effectiveness and safety

While albiglutide demonstrated good glycemic efficacy and tolerability, adverse effects included upper respiratory tract infections, diarrhea, nausea, and injection site reactions

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Exendin-9 administered IP was unable to block this effect, indicating a dominant role for CNS GLP-1R populations (77)

Testosterone propionate offers more frequent dosing requirements but provides tighter hormone control and less water retention