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Detoxification enzymes of phase II compete with the activating enzymes of phase I to restrict the generation of electrophiles and catalyze the conversion of these electrophilic molecules to inactivate conjugates, making them more soluble in water and more easily get excreted from the body

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In recent years, an increasing number of studies have shown that elucidating the urate transporters is essential to address the balance of urate homeostasis and hyperuricaemia-related diseases

Yang D, Elner SG, Bian ZM, Till GO, Petty HR, Elner VM

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Mediouni, S