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When zonulin levels are elevated, these junctions become loose, leading to increased intestinal permeabilityor leaky gut

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It was originally approved to treat type 2 diabetes, where it already demonstrated heart-protective benefits

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Pizzimenti, S., Toaldo, C., Pettazzoni, P., Dianzani, M

GLP-1 peptides, FDA-approved for type-2 diabetes (e.g., Semaglutide and Exenatide) and weight loss (Semaglutide) have been studied for their effects on alcohol use in both preclinical and clinical studies (for a detailed review: 10)