It is also a co-factor for GPX4-mediated lipid detoxification 35 , and GPX4 activity is necessary for the survival of several tissues, including the liver 36 and kidney 37
Eli Lilly recently announced positive results in its phase III clinical trials of orfoglipron, which is licensed from Chugai Pharmaceutical Co
If coffee feels harder to tolerate, you might try having it with food or adjusting the type (for example, cold brew vs
(I am a big advocate of spacing out doses for people who have reached their goal weight, OR who are taking GLP-1s primarily for a possible metabolic/anti-inflammatory benefit, and who want to keep their weight neutral.) But maintenance dosing after achieving a clinical response is a completely different concept from starting at a sub-therapeutic dose and hoping it works
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
Patients with Wilsons disease (a rare disorder affecting copper metabolism) or known copper hypersensitivity should avoid GHK-Cu
