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If fatigue persists beyond the initial adjustment period, discuss with your provider whether semaglutide fatigue management strategies are appropriate

Symptoms that deserve prompt medical attention include: severe abdominal pain pain that spreads to the back repeated vomiting signs of dehydration yellowing of the skin or eyes upper right abdominal pain, especially with fever or vomiting symptoms of low blood sugar, such as shakiness, sweating, confusion, or rapid heartbeat swelling of the face, lips, tongue, or throat trouble breathing a lump or swelling in the neck, hoarseness, or trouble swallowing The point is not to expect these problems

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In the fed state, postprandial metabolism is essentially characterized by high insulin levels that are responsible for antilipolytic action (e.g., by inhibiting HSL) and antigluconeogenic action (by suppressing this metabolic pathway) as well as for lipogenic action (e.g., by stimulating LPL) [87,117]

Studies thus far suggest semaglutide is generally safe for long-term use, though its been linked to a higher risk of gallbladder issues with longer use

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