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Although BAs can regulate ferroptosis-related molecules via FXR activation and Lactobacillus metabolites possess Nrf2 activation potential, direct experimental evidence for their effects in PCOS ovarian granulosa cells is still lacking
This defect is associated with reduced cytotoxicity and impaired anti-tumor activity (108)
A meta-analysis also showed that GLP-1 RAs could reduce depression severity scores, with a greater impact on diabetic participants [Reference Pozzi, Mazhar, Peeters, Vantaggiato, Nobile, Clementi and Nobile50]
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Age, sex, BMI, diabetes status, genetic markers, microbiome composition, and lifestyle factors all influence outcomes
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