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In addition to these physiological mechanisms, biopsychosocial factorssuch as the higher prevalence of central sensitization syndromes and mood disorders among patients with IBS, and particularly IBS-Mmay also contribute to the observed differences [28,29]

Bose P, Masarova L, Pemmaraju N, Bledsoe SD, Daver NG, Jabbour EJ, Kadia TM, Estrov ZE, Kornblau SM, Andreeff M , Jain N, Cortes JE, Borthakur G, Alvarado Y, Richie MA, Dobbins MH, McCrackin SA, Zhou L, Pierce SA, Wang X, Pike AM, Garcia-Manero G, Kantarjian HM, Verstovsek S

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