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Adolescent THC exposure causes enduring prefrontal cortical disruption of GABAergic inhibition and dysregulation of sub-cortical dopamine function

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2,539 adult clinical trial showed weight loss from 15% to 35% weight loss versus placebo group.

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Patients should be monitored for diabetic retinopathy complications (especially if on insulin with rapid HbA1c improvement), gallbladder disease, and signs of dehydration or acute kidney injury

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