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Researchers think the pain relief after using BPC-157 comes mainly from calming inflammation, not from blocking pain signals directly

Nasal spray considerations: Typically lower bioavailability than injection, requiring somewhat higher doses Faster onset in some users due to direct CNS access More convenient and less intimidating for needle-averse individuals Requires properly calibrated spray bottles for accurate dosing Converting from injectable to nasal dosing is not straightforward

Both systemic injection (intramuscular) and local application (directly at the bone defect) produced healing improvements

Treatment of BCG-infected iNOS -/- macrophages with LPS/IFN, induced killing of about 75% of intracellular BCG after 72 hours

10.1007/s11103-016-0531-2 80 KirlyL.KnstlerA.HllerK.FattingerM.JuhszC.MllerM.et al

Clinical practitioners often pair this method with PRP or exosome therapy for compounded results